In this issue of Danish Pharmacovigilance Update:
- Cases of necrotising fasciitis associated with the use of bevacizumab (Avastin®) (front page)
- Tolvaptan (Samsca®) and potential risk of hepatic injury (p 2)
- Liver fibrosis reported as a potential adverse reaction from the use of methotrexate (p 3)
- The European Medicines Agency (EMA) has started a review of the efficacy and risks of combined use of renin-angiotensin system(RAS)-blocking agents (p 4)